protein

OX40 Ligand protein

MBS539580

0.01 mg

310 USD

Recombinant Protein

OX40 Ligand protein

OX40

OX40 Ligand; OX40L protein; OX Ligand-40; CD252 protein; OX Ligand-40 protein; OX Ligand 40 protein; Gp34 protein; TNFSF4 protein; OX Ligand 40

OX40 ligand, partial; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD_antigen: CD252

OX40

TNFSF4; TNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TXGP1; OX40L

TNFL4_HUMAN

Human

67

> 97% pure

Supplied as a lyophilized powder

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL2, IL3, and IFN. Bioactivity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: Hi-5 cells

Immunology

Purified recombinant Human OX40 Ligand protein

11275538

BAB18304.1

P23510

15.5-25 kDa

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!TSLP Signaling Pathway 672451

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

0.01 mg

310 USD