protein

Relaxin 2 protein

MBS539570

0.025 mg

310 USD

Recombinant Protein

Relaxin 2 protein

Relaxin 2

Relaxin-2 protein; Relaxin 2; RLN2 protein; Relaxin-2; H2 relaxin protein; Relaxin 2 protein

Relaxin 2; Prorelaxin H2; prorelaxin H2; relaxin 2

RLN2; RLN2; H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2

REL2_HUMAN

Human

185

Region of Relaxin 2 protein corresponding to amino acids (A-Chain): QLYSALANKC CHVGCTKRSL ARFC and (B-Chain): DSWMEEVIKL CGRELVRAQI AICGMSTWS.

> 98% pure

Supplied as a lyophilized powder

25 ug lyophilized

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

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Protein Type: Recombinant. Biological Significance: Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an ?orphan? G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: E Coli

Hormones & Steroids

Purified recombinant Human Relaxin 2 protein

116497221

AAI26416.1

P04090

6.0 kDa

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Peptide Ligand-binding Receptors Pathway (106358); Relaxin Receptors Pathway (161022); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

RLN2: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular region. Molecular Function: hormone activity. Biological Process: female pregnancy

0.025 mg

310 USD