BMP6 protein | MyBioSource MBS539568 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

BMP6 protein

catalog :

MBS539568

quantity :

0.01 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539568

products type :

Recombinant Protein

products full name :

BMP6 protein

products short name :

BMP6

products name syn :

BMP 6 protein; VGR protein; BMP6; Bone Morphogenetic protein 6 protein; BMP-6; BMP-6 protein; BMP 6

other names :

bone morphogenetic protein 6, partial; Bone morphogenetic protein 6; bone morphogenetic protein 6; bone morphogenetic protein 6; VG-1-related protein; VG-1-R; VGR-1

products gene name :

BMP6

other gene names :

BMP6; BMP6; VGR; VGR1; VGR; BMP-6; VG-1-R; VGR-1

uniprot entry name :

BMP6_HUMAN

host :

Human

sequence length :

sequence :

Region of BMP6 protein corresponding to amino acids VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH.

purity :

> 95% pure

form :

Lyophilized from 10mM Tris, pH 9.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: TGF beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Bioactivity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: HEK cells

products categories :

Differentiation & Development

products description :

Purified recombinant Human BMP6 protein

ncbi gi num :

3492993

ncbi acc num :

AAC33283.1

uniprot acc num :

P22004

ncbi mol weight :

26.2 kDa

ncbi pathways :

BMP Receptor Signaling Pathway (137948); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Endochondral Ossification Pathway (198812); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Id Signaling Pathway (198871); Ovarian Steroidogenesis Pathway (790011); Ovarian Steroidogenesis Pathway (795173); TGF-beta Signaling Pathway (83064)

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

uniprot summary :

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 6p24-p23. Cellular Component: extracellular space; cytoplasm. Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; BMP signaling pathway; regulation of apoptosis; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; eye development; positive regulation of protein secretion; regulation of MAPKKK cascade; cartilage development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; immune response; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth

size1 :

0.01 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage