product summary
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company name :
MyBioSource
product type :
protein
product name :
TLR3 protein
catalog :
MBS539535
quantity :
0.025 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS539535
products type :
Recombinant Protein
products full name :
TLR3 protein
products short name :
TLR3
products name syn :
TLR3; CD283 antigen protein; TLR-3 protein; TLR-3; Toll-like receptor 3; TLR 3 protein; TLR 3
other names :
toll-like receptor 3; Toll-like receptor 3; toll-like receptor 3; toll-like receptor 3; Toll-like receptor 3
products gene name :
TLR3
other gene names :
Tlr3; Tlr3
uniprot entry name :
Q7TNI8_RAT
host :
Human
sequence length :
905
sequence :
Region of TLR3 protein corresponding to amino acids STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAANFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ LSDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLSSTK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LSSNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIRNL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAWLPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLASL PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLSNSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFALVPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNLESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK SLNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNWINE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L.
purity :
> 95% pure
form :
Supplied as a lyophilized powder
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Protein Type: Recombinant. Biological Significance: TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-?B pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Bioactivity: Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r). The ED50for this effect is approximately 30 ug/ml in the presence of 100 ug/ml of Poly I:C. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
other info2 :
Expression System: 293 cells
products categories :
Cytokines & Growth Factors
products description :
Purified recombinant Human TLR3 protein
ncbi gi num :
38454316
ncbi acc num :
NP_942086.1
ncbi gb acc num :
NM_198791.1
uniprot acc num :
Q7TNI8
ncbi mol weight :
77 kDa
ncbi pathways :
Hepatitis B Pathway 694795!!Hepatitis C Pathway 173970!!Hepatitis C Pathway 173907!!Herpes Simplex Infection Pathway 377869!!Herpes Simplex Infection Pathway 377865!!Immune System Pathway 1177885!!Influenza A Pathway 217170!!Influenza A Pathway 217150!!Innate Immune System Pathway 1177914!!Toll-Like Receptors Cascades Pathway 1177915
ncbi summary :
human homolog induces activation of NF-kappaB; mouse homolog plays a role in the production of inflammatory cytokines [RGD, Feb 2006]
size :
0.025 mg
price :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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