APRIL protein | MyBioSource MBS539497 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

APRIL protein

catalog :

MBS539497

quantity :

0.01 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539497

products type :

Recombinant Protein

products full name :

APRIL protein

products short name :

APRIL

products name syn :

TNFSF13 protein; TRDL-1a protein; TRDL-1 alpha protein; A Proliferating-inducing Ligand protein

other names :

tumor necrosis factor ligand superfamily member 13 isoform eta; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor (ligand) superfamily, member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256

products gene name :

APRIL

other gene names :

TNFSF13; TNFSF13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715; APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1

uniprot entry name :

TNF13_HUMAN

host :

Human

sequence length :

205

sequence :

Region of APRIL protein corresponding to amino acids AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL.

purity :

> or = 95% pure by SDS-PAGE gel and HPLC

form :

Lyophilized powder from 10mM Sodium Phosphate, pH7.5 plus 500mM NaCl plus 5% Trehalose. Centrifuge the vial prior to opening. Reconstitute by adding water to a concentration of 0.1-0.5mg/ml. Do not vortex.

concentration :

10ug lyophilized

storage stability :

Ships ambient or refrigerated. After receipt, store at 4 degree C short term, -20 degree C long term.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Bioactivity: Tested by its ability to induce IgM secretion by CpG/CD40L treated human naive B cells, at a concentration of 500ng/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: Hi-5 cells. Biohazard: Use appropriate laboratory precautions when handling this product.

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human APRIL protein

ncbi gi num :

310750389

ncbi acc num :

NP_001185553.1

ncbi gb acc num :

NM_001198624.1

uniprot acc num :

O75888

ncbi mol weight :

16.3 kDa

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Gene Expression Pathway (105937); HuR Stabilizes MRNA Pathway (187216); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway (187211); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269); Spinal Cord Injury Pathway (739007)

ncbi summary :

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

uniprot summary :

TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol; external side of plasma membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; gene expression; signal transduction; positive regulation of isotype switching to IgA isotypes

size1 :

0.01 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage