catalog number :
MBS539490
products type :
Recombinant Protein
products full name :
p16 INK4 alpha protein
products short name :
p16 INK4 alpha
products name syn :
p INK4 alpha 16 protein; p INK4 alpha-16; p16-INK4 protein; Cyclin-dependent kinase inhibitor 2A protein; MTS-1 protein; p16INK4A protein; Cyclin-dependent kinase 4 inhibitor A protein; p16 INK-4 alpha protein; p16 INK4 alpha; p INK4 alpha-16 protein; p INK4 alpha 16; CDK4I protein; Multiple tumor suppressor 1 protein
products gene name :
p16 INK4 alpha
sequence :
Region of p16 INK4 alpha protein corresponding to amino acids MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD.
form :
Supplied as a lyophilized powder
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Protein Type: Recombinant. Biological Significance: p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
other info2 :
Expression System: E Coli
products categories :
Cell Cycle & Cell Death
products description :
Purified recombinant Human p16 INK4 alpha protein
ncbi mol weight :
16.5 kDa