MyBioSource

protein

TGF beta 3 protein

MBS539483

0.002 mg

320 USD

MBS539483

Recombinant Protein

TGF beta 3 protein

TGF beta 3

Transforming Growth Factor-beta3 protein; TGF beta 3; TGF beta-3 protein; TGF-3b protein; TGF beta 3; TGF beta-3 protein; TGF beta-3; TGFB3 protein; TGF beta 3 protein

transforming growth factor beta-3 preproprotein; Transforming growth factor beta-3; transforming growth factor beta-3; TGF-beta-3; transforming growth factor, beta 3; N/A

TGF beta 3

TGFB3; TGFB3; ARVD; TGF-beta3; TGF-beta-3

TGFB3_HUMAN

Sf-9 insect cells

Human

>98% pure by SDS PAGE and HPLC

Supplied as a lyophilized powder

Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Endotoxin Level: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Cytokines & Growth Factors; Proteins; Native & Recombinant Proteins; Recombinant

Purified recombinant Human TGF beta 3 protein. The three mammalian isoforms of TGF beta, TGF beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1.

4507465

NP_003230.1

NM_003239.2

P10600

47,328 Da

ALK1 Signaling Events Pathway 137968!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chronic Myeloid Leukemia Pathway 83116!!Chronic Myeloid Leukemia Pathway 528!!Colorectal Cancer Pathway 83106

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

Function: Involved in embryogenesis and cell differentiation. Subunit structure: Homodimer; disulfide-linked. Interacts with ASPN. Ref.8. Subcellular location: Secreted. Involvement in disease: Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [. MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Ref.10. Sequence similarities: Belongs to the TGF-beta family. Sequence caution: The sequence CAA33024.1 differs from that shown. Reason: Erroneous initiation.

0.002 mg

320 USD