protein

ENA78 protein

MBS539471

0.02 mg

310 USD

Recombinant Protein

ENA78 protein

ENA78

ENA-78; ENA-78 protein; ENA78; ENA 78; ENA 78 protein; CXCL5 protein; Epithelial Neutrophil Activating Peptide-78 protein

ENA-78; C-X-C motif chemokine 5; C-X-C motif chemokine 5; chemokine (C-X-C motif) ligand 5; ENA-78(1-78); Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; Small-inducible cytokine B5

ENA78

CXCL5; CXCL5; SCYB5; ENA-78; ENA78; SCYB5

CXCL5_HUMAN

Human

114

Region of ENA78 protein corresponding to amino acids LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N.

> 98% pure

Supplied as a lyophilized powder

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The Mouse homolog of ENA-78 is called LIX. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Bioactivity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: E Coli

Cytokines & Growth Factors

Purified recombinant Human ENA78 protein

471243

CAA55355.1

P42830

8 kDa

Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!G Alpha (i) Signalling Events Pathway 119550!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Peptide Ligand-binding Receptors Pathway 106358

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

0.02 mg

310 USD