MyBioSource

protein

Angiopoietin 1 protein

MBS539452

0.02 mg

320 USD

MBS539452

Recombinant Protein

Angiopoietin 1 protein

Angiopoietin 1

AGPT protein; ANGPT 1 protein; ANG1 protein; ANG 1 protein; KIAA0003 protein; Angiopoietin 1; Angiopoietin 1; ANGPT1 protein; AGP1 protein; AGP 1 protein; Angiopoietin -1; Angiopoietin -1 protein; Angiopoietin1 protein; Angiopoietin 1 protein

angiopoietin-1 isoform 1; Angiopoietin-1; angiopoietin-1; ANG-1; angiopoietin 1; N/A

ANGPT1; ANGPT1; AGP1; AGPT; ANG1; KIAA0003; ANG-1

ANGP1_HUMAN

HeLa cells

Human

>95% pure by SDS PAGE and HPLC

Supplied as a lyophilized powder

Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Endotoxin Level: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Bioactivity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC).

Differentiation & Development; Proteins; Native & Recombinant Proteins; Recombinant

Purified recombinant Human Angiopoietin 1 protein. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells. Ang-1/ Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system. Transgenic mice lacking expression of either Ang-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth.

20532340

NP_001137.2

NM_001146.3

Q15389

57,513 Da

Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Hemostasis Pathway 106028!!Rheumatoid Arthritis Pathway 200309!!Rheumatoid Arthritis Pathway 200269!!Tie2 Signaling Pathway 106063

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Ref.6 Ref.8 Ref.9 Ref.10. Subunit structure: Homooligomer. Interacts with TEK/TIE2. Ref.6 Ref.7 Ref.8. Subcellular location: Secreted. Post-translational modification: Glycosylated. Miscellaneous: It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart. Sequence similarities: Contains 1 fibrinogen C-terminal domain. Sequence caution: The sequence BAA02793.2 differs from that shown. Reason: Erroneous initiation.

0.02 mg

320 USD