protein

sDLL4 protein

MBS539451

0.025 mg

310 USD

Recombinant Protein

sDLL4 protein

sDLL4

sDLL-4 protein; sDLL 4 protein; sDLL 4; sDLL4; Delta-like protein 4; Drosophila Delta homolog 4 protein; sDLL-4

delta-like protein 4; Delta-like protein 4; delta-like protein 4; delta-like 4 (Drosophila); Drosophila Delta homolog 4; Delta4

sDLL4

DLL4; DLL4; hdelta2; Delta4

DLL4_HUMAN

Human

685

Region of SDLL4 protein corresponding to amino acids SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP.

> 95% pure

Supplied as a lyophilized powder

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Bioactivity: The sDLL-4, when immobilized at concentrations >1.5 ug/mL will inhibit myogenesis in C2C12 cells. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: 293 cells

Cytokines & Growth Factors

Purified recombinant Human sDLL4 protein

9506545

NP_061947.1

NM_019074.3

Q9NR61

54 kDa

Activated NOTCH1 Transmits Signal To The Nucleus Pathway (576270); Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway (771591); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (771595); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (771593); Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway (771589); Delta-Notch Signaling Pathway (198879); Disease Pathway (530764); Diseases Of Signal Transduction Pathway (1183518); NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway (771602); Neural Crest Differentiation Pathway (672460)

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium. Protein type: Membrane protein, integral; Cell development/differentiation. Chromosomal Location of Human Ortholog: 15q14. Cellular Component: integral to membrane; plasma membrane. Molecular Function: calcium ion binding; Notch binding. Biological Process: patterning of blood vessels; negative regulation of cell proliferation; Notch signaling pathway; regulation of neurogenesis; visual perception; blood circulation; Notch receptor processing; blood vessel remodeling; negative regulation of transcription from RNA polymerase II promoter; angiogenesis; signal transduction

0.025 mg

310 USD