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protein

BAFF Receptor protein

MBS539429

0.05 mg

320 USD

MBS539429

Recombinant Protein

BAFF Receptor protein

BAFF Receptor

BAFFR protein; TNFRSF13C protein

BAFF receptor; BAFF receptor; tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor; tumor necrosis factor receptor superfamily, member 13C; N/A

BAFF Receptor

TNFRSF13C; TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BAFF-R

Q5H8V1_HUMAN

E.coli

Human

Region of BAFF Receptor protein corresponding to amino acids MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG.

> or = 95% pure by SDS PAGE gel and HPLC

0.2 micron filtered, lyophilzed from 0.5 x PBS, pH 7.2. Centrifuge vial prior to opening. Reconstitute, in water to a concentration of 0.1-1.0mg/ml. Do not vortex.

50ug, lyophilized

Upon receipt store at 4 degree C short-term, -20 degree C long term. After reconstituted, it is recommended to further dilute in a buffer containing a carrier protein and store at 4 degree C short term or -20 degree C long term. Avoid repeated freeze/thaw cycles.

Endotoxin Level: Endotoxin level is less than 0.1 ng per ug (1 EU/ug) . Bioactivity: Determined by its ability to bl DEG Ck BAFF induced mouse splen DEG Cyte survival. Additional Remarks: The expected ED50 for this effect is 2.0-4.0 ug/ml in the presence of 1.0ug/ml of human soluble BAFF.

Biohazard: Use standard laboratory precautions when handling this material

Cytokines & Growth Factors; Proteins; Native & Recombinant Proteins; Recombinant

Purified recombinant Human BAFF Receptor protein. BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation.

15208475

AAK91826.1

Q5H8V1

7.7 kDa

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!NF-kappa B Signaling Pathway 634527!!Primary Immunodeficiency Pathway 83125!!Primary Immunodeficiency Pathway 537

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

0.05 mg

320 USD