CD137L protein | MyBioSource MBS539418 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

CD137L protein

catalog :

MBS539418

quantity :

0.02 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539418

products type :

Recombinant Protein

products full name :

CD137L protein

products short name :

CD137L

products name syn :

TNFSF9 protein; CDL-137 protein; CDL 137 protein; 4-1BB protein; CDL-137; CD137L; CDL 137

other names :

4-1BB ligand; Tumor necrosis factor ligand superfamily member 9; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; 4-1BB ligand; 4-1BBL

products gene name :

CD137L

other gene names :

TNFSF9; TNFSF9; CD137L; 4-1BB-L; 4-1BBL

uniprot entry name :

TNFL9_HUMAN

host :

Human

sequence length :

254

sequence :

Region of CD137 protein corresponding to amino acids MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE.

purity :

> or = 98% by SDS-PAGE gel and HPLC analysis

form :

Lyophilized from 5mM Tris, pH8.0, with 75mM NaCl. Centrifuge vial prior to opening. Reconstitute in water to 0.1-1.0mg/ml. Do not vortex.

concentration :

20 ug, lyophilized.

storage stability :

Upon receipt store at 4 degree C shor term, -20 degree C long term. Avoid repeat freeze-thaws once reconstitute.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: CD137L or 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Bioactivity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml. Please Note: Results may vary with PBMC donors. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: E Coli. Biohazard: Use standard laboratory precautions when handling this material.

products categories :

Immunology

products description :

Purified recombinant Human CD137L protein

ncbi gi num :

571323

ncbi acc num :

AAA53134.1

uniprot acc num :

P41273

ncbi mol weight :

19.5 kDa

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

ncbi summary :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

uniprot summary :

TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. Protein type: Membrane protein, integral; Apoptosis; Cytokine; Cell cycle regulation. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular space; plasma membrane; integral to membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: cell proliferation; positive regulation of interferon-gamma production; positive regulation of cytotoxic T cell differentiation; cell-cell signaling; positive regulation of interleukin-12 production; apoptosis; positive regulation of interleukin-6 production; immune response; myeloid dendritic cell differentiation; signal transduction; positive regulation of activated T cell proliferation

size1 :

0.02 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage