CYR61 protein | MyBioSource MBS539410 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

CYR61 protein

catalog :

MBS539410

quantity :

0.02 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539410

products type :

Recombinant Protein

products full name :

CYR61 protein

products short name :

CYR61

products name syn :

CYR61; CYR6-1 protein; CYR-61 protein; CYR 61; CYR 61 protein; CYR-61; CCN1 protein; GIGI protein protein

other names :

CYR61; CYR61 protein; protein CYR61; cysteine-rich, angiogenic inducer, 61; CYR61 protein

products gene name :

CYR61

other gene names :

CYR61; CYR61; CCN1; GIG1; IGFBP10

uniprot entry name :

Q6FI18_HUMAN

host :

Human

sequence length :

381

sequence :

Region of CYR61 protein corresponding to amino acids MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPVRFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGETF SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD.

purity :

> 95% pure

form :

Supplied as a lyophilized powder

concentration :

20ug per vial; lyohpilized

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK). Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Mouse 3T3 cells. The expected ED50 for this effect is 2.0-3.0 ug/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: E Coli

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human CYR61 protein

ncbi gi num :

49168524

ncbi acc num :

CAG38757.1

uniprot acc num :

Q6FI18

ncbi mol weight :

42,027 Da

ncbi pathways :

Hypertrophy Model Pathway (198828); Oncostatin M Signaling Pathway (711361); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); RhoA Signaling Pathway (169356); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

uniprot summary :

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p22.3. Cellular Component: extracellular matrix; proteinaceous extracellular matrix. Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; extracellular matrix binding. Biological Process: extracellular matrix organization and biogenesis; anatomical structure morphogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; cell proliferation; positive regulation of osteoblast differentiation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of BMP signaling pathway; positive regulation of cell migration; negative regulation of apoptosis

size1 :

0.02 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage