protein

LIX protein (Mouse)

MBS539407

0.02 mg

310 USD

Recombinant Protein

LIX protein (Mouse)

LIX

CXCL5 protein; ENA-78 protein

LIX; C-X-C motif chemokine 5; C-X-C motif chemokine 5; chemokine (C-X-C motif) ligand 5; Cytokine LIX; Small-inducible cytokine B5

LIX

Cxcl5; Cxcl5; LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II; Scyb5

CXCL5_MOUSE

Mouse

132

Region of LIX protein corresponding to amino acids APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SVQ.

> 98% pure

Supplied as a lyophilized powder

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: The Mouse homolog of ENA-78 is called LIX. ENA-78/LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78/LIX is a chemoattractant for neutrophils. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78/LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Bioactivity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: E Coli

Cytokines & Growth Factors

Purified recombinant Mouse LIX protein

950159

AAC52238.1

P50228

9.8 kDa

Chemokine Receptors Bind Chemokines Pathway 1168363!!Chemokine Signaling Pathway 99271!!Chemokine Signaling Pathway 672435!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 1168361!!Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!G Alpha (i) Signalling Events Pathway 1168392!!GPCR Downstream Signaling Pathway 1168390!!GPCR Ligand Binding Pathway 1168360

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]

0.02 mg

310 USD