VEGF D protein | MyBioSource MBS539402 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

VEGF D protein

catalog :

MBS539402

quantity :

0.01 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539402

products type :

Recombinant Protein

products full name :

VEGF D protein

products short name :

VEGF D

products name syn :

FIGF protein; Vascular Endothelial Growth Factor-D protein

other names :

vascular endothelial growth factor D preproprotein; Vascular endothelial growth factor D; vascular endothelial growth factor D; c-fos induced growth factor (vascular endothelial growth factor D); c-Fos-induced growth factor; FIGF

products gene name :

VEGF D

other gene names :

FIGF; FIGF; VEGFD; VEGF-D; VEGFD; VEGF-D; FIGF

uniprot entry name :

VEGFD_HUMAN

host :

Human

sequence length :

354

sequence :

Region of VEGF D protein corresponding to amino acids FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR.

purity :

> 95% pure

form :

Supplied as a lyophilized powder

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: 293 cells

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human VEGF D protein

ncbi gi num :

4758378

ncbi acc num :

NP_004460.1

ncbi gb acc num :

NM_004469.4

uniprot acc num :

O43915

ncbi mol weight :

40,444 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Hemostasis Pathway (106028); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105); Platelet Activation, Signaling And Aggregation Pathway (106034)

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

uniprot summary :

VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: Xp22.31. Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding; chemoattractant activity. Biological Process: cell proliferation; platelet activation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation; blood coagulation; induction of positive chemotaxis

size1 :

0.01 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage