PDGF CC protein | MyBioSource MBS539400 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

PDGF CC protein

catalog :

MBS539400

quantity :

0.02 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539400

products type :

Recombinant Protein

products full name :

PDGF CC protein

products short name :

PDGF CC

products name syn :

Osteosarcoma-derived Growth Factor protein; Platelet-Derived Growth Factor-CC protein; ODGF protein; Glioma-derived growth factor protein; PCGF protein; GDGF protein

other names :

Platelet-derived growth factor C; Platelet-derived growth factor C; platelet-derived growth factor C; platelet derived growth factor C; Fallotein; Spinal cord-derived growth factor; SCDGF

products gene name :

PDGF CC

other gene names :

PDGFC; PDGFC; SCDGF; FALLOTEIN; SCDGF; PDGF-C; SCDGF; PDGFC latent form; PDGFC receptor-binding form

uniprot entry name :

PDGFC_HUMAN

host :

Human

sequence length :

345

sequence :

Region of PDGF CC protein corresponding to amino acids MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG.

purity :

> 98% pure

form :

Supplied as a lyophilized powder

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-a and PDGFR-beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: E Coli

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human PDGF CC protein

ncbi gi num :

205830662

ncbi acc num :

Q9NRA1.2

ncbi mol weight :

20,609 Da

ncbi pathways :

Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Gap Junction Pathway (83072); Gap Junction Pathway (483); Melanoma Pathway (83114)

ncbi summary :

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

uniprot summary :

PDGFC: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q32. Cellular Component: Golgi membrane; extracellular space; cell surface; endoplasmic reticulum lumen; cytoplasm; extracellular region; plasma membrane; nucleus. Molecular Function: protein binding; protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding. Biological Process: embryonic development; positive regulation of fibroblast proliferation; organ morphogenesis; central nervous system development; transmembrane receptor protein tyrosine kinase activation (dimerization); positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; positive regulation of DNA replication

size1 :

0.02 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage