product summary
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company name :
MyBioSource
product type :
protein
product name :
PAI2 protein
catalog :
MBS539367
quantity :
0.01 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS539367
products type :
Recombinant Protein
products full name :
PAI2 protein
products short name :
PAI2
products name syn :
Plasminogen Activator Inhibitor-2 protein; Urokinase Inhibitor protein; PAI 2; PAI-2 protein; PAI2; PAI 2 protein; PAI-2
other names :
plasminogen activator inhibitor 2; Plasminogen activator inhibitor 2; plasminogen activator inhibitor 2; serpin peptidase inhibitor, clade B (ovalbumin), member 2; Monocyte Arg-serpin; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor
products gene name :
PAI2
other gene names :
SERPINB2; SERPINB2; PAI; PAI2; PAI-2; PLANH2; HsT1201; PAI2; PLANH2; PAI-2
uniprot entry name :
PAI2_HUMAN
host :
Human
sequence length :
415
sequence :
Region of PAI2 protein corresponding to amino acids MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF NEVGANAVT PMTPENFTSC GFMQQIQKGS YPDAILQAQA ADKIHSSFRS LSSAINASTG N YLLESVNK LFGEKSASFR EEYIRLCQKY YSSEPQAVDF LECAEEARKK INSWVKTQTK GK IPNLLPE GSVDGDTRMV LVNAVYFKGK WKTPFEKKLN GLYPFRVNSA QRTPVQMMYL REK LNIGYI EDLKAQILEL PYAGDVSMFL LLPDEIADVS TGLELLESEI TYDKLNKWTS KDKM AEDEV EVYIPQFKLE EHYELRSILR SMGMEDAFNK GRANFSGMSE RNDLFLSEVF HQAMV DVNE EGTEAAAGTG GVMTGRTGHG GPQFVADHPF LFLIMHKITN CILFFGRFSS P.
purity :
> 95% pure
form :
Lyophilized from 50MM CH3COONa, with 100mM NaCl. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Protein Type: Recombinant. Biological Significance: PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47 kDa nonglycosylated intracellular protein which can be induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated forms of PAI-2 are equally effective as inhibitors of urokinase-type plasminogen activator (uPA), the only established physiological target of this serpin. PAI-2 has a unique ability to form dormant polymers spontaneously and reversibly under physiological conditions. Bioactivity: Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 370C. Half maximal inhibition against 1.0 ug/ml of single chain tPA was obtained at a concentration of 1.0 ug/ml. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
other info2 :
Expression System: E Coli
products categories :
Proteases, Inhibitors, & Enzymes
products description :
Purified recombinant Human PAI2 protein
ncbi gi num :
219689110
ncbi acc num :
NP_001137290.1
ncbi gb acc num :
NM_001143818.1
uniprot acc num :
P05120
ncbi mol weight :
46,596 Da
ncbi pathways :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Blood Clotting Cascade Pathway (198840); Dissolution Of Fibrin Clot Pathway (106061); Hemostasis Pathway (106028); Senescence And Autophagy Pathway (198780)
uniprot summary :
SERPINB2: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1. Belongs to the serpin family. Ov-serpin subfamily. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 18q21.3. Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity. Biological Process: fibrinolysis; blood coagulation; negative regulation of apoptosis
size1 :
0.01 mg
price1 :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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