catalog number :
MBS538329
products type :
Recombinant Protein
products full name :
ILGFBP1 protein
products short name :
ILGFBP1
products name syn :
ILGFBP-1; hIGFBP-1 protein; PP12 protein; ILGFBP1; ILGFBP 1; ILGFBP-1 protein; AFBP protein; ILGFBP 1 protein; IGF-BP25 protein; IGF-Binding Protein 1 protein; IBP-1 protein; IGFBP-1 protein; Insulin Like Growth Factor Binding Protein 1 protein
other names :
insulin-like growth factor-binding protein 1; Insulin-like growth factor-binding protein 1; insulin-like growth factor-binding protein 1; insulin-like growth factor binding protein 1; Placental protein 12; PP12
products gene name :
ILGFBP1
other gene names :
IGFBP1; IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12
uniprot entry name :
IBP1_HUMAN
form :
Supplied as a lyophilized powder. Reconstitute in 20mM CH3COOH at the stock concentration of not less than 0.1mg/ml.
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Protein Type: Recombinant. Biological Significance: IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Bioactivity: Inhibition of IGF-I stimulated proliferation of NUC-1 cells: IC50 ~ 100 ng/ml Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures: IC50 (1% serum) ~300 ng/ml.
other info2 :
Expression System: E Coli
products categories :
Cytokines & Growth Factors
products description :
Purified recombinant Human ILGFBP1 protein
ncbi acc num :
NP_000587.1
ncbi gb acc num :
NM_000596.2
ncbi mol weight :
25.3 kDa
ncbi pathways :
ATF4 Activates Genes Pathway 530772!!AhR Pathway 755436!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!HIF-1-alpha Transcription Factor Network Pathway 138045!!Metabolism Of Proteins Pathway 106230!!Myometrial Relaxation And Contraction Pathways 198759!!PERK Regulates Gene Expression Pathway 105907!!Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908!!Unfolded Protein Response (UPR) Pathway 105904
ncbi summary :
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]