protein

FGF8 protein

MBS538302

0.025 mg

310 USD

Recombinant Protein

FGF8 protein

FGF8

FGF-8 protein; FGF8; FGF-8b protein; AIGF protein; FGF-8; FGF 8; FGF 8 protein; HBGF protein; Fibroblast Growth Factor-8 protein

fibroblast growth factor 8 isoform A; Fibroblast growth factor 8; fibroblast growth factor 8; fibroblast growth factor 8 (androgen-induced); Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8

FGF8

FGF8; FGF8; HH6; AIGF; KAL6; FGF-8; HBGF-8; AIGF; FGF-8; AIGF; HBGF-8

FGF8_HUMAN

Human

204

Region of FGF8 protein corresponding to amino acids MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR.

> 95% pure

Lyophilized from 10mM Tris, pH 8.0 with 75mM NaCl. Reconstitute in 10 mM Tris, pH 8.0.

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: FGF8 (FGF8b) is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF8A, FGF8B, FGF8E and FGF8F. The human and Mouse FGF8 A and B are identical unlike human and mouse FGF8 E and F are 98% identical. FGF8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Bioactivity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF- receptors is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6 units/mg. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: E Coli

Cytokines & Growth Factors

Purified recombinant Human FGF8 protein

15147350

NP_149355.1

NM_033165.3

P55075

22.4 kDa

Activated Point Mutants Of FGFR2 Pathway 645281!!Adaptive Immune System Pathway 366160!!Constitutive Signaling By Aberrant PI3K In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764!!Diseases Of Signal Transduction Pathway 1183518!!Downstream Signal Transduction Pathway 106385!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250!!Downstream Signaling Of Activated FGFR1 Pathway 1183557

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

0.025 mg

310 USD