PTHrP protein | MyBioSource MBS538263 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

PTHrP protein

catalog :

MBS538263

quantity :

0.01 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS538263

products type :

Recombinant Protein

products full name :

PTHrP protein

products short name :

PTHrP

products name syn :

Parathyroid Hormone-related Protein protein

other names :

parathyroid hormone-related protein isoform 2 preproprotein; Parathyroid hormone-related protein; parathyroid hormone-related protein; parathyroid hormone-like hormone; Parathyroid hormone-like protein; PLP

products gene name :

PTHrP

other gene names :

PTHLH; PTHLH; HHM; PLP; BDE2; PTHR; PTHRP; PTHRP; PTH-rP; PTHrP; PLP

uniprot entry name :

PTHR_HUMAN

host :

Human

sequence length :

175

sequence :

Region of PTHrP protein corresponding to amino acids AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTP.

purity :

> 98% pure

form :

Lyophilized from PBS, pH 7.1. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml.

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: PTHrP is a polypeptide hormone produced by almost every tissue of the body. PTHrP is closely related to parathyroid hormone (PTH), which is secreted from the parathyroid gland, and plays a central role in regulating the extracellular concentrations of calcium and phosphorous. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: E Coli

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human PTHrP protein

ncbi gi num :

4506269

ncbi acc num :

NP_002811.1

ncbi gb acc num :

NM_002820.2

uniprot acc num :

P12272

ncbi mol weight :

9.8 kDa

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (106378); Endochondral Ossification Pathway (198812); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356); Signaling Events Mediated By The Hedgehog Family Pathway (137950)

ncbi summary :

The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]

uniprot summary :

PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12p12.1-p11.2. Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cytoplasm; extracellular region. Molecular Function: peptide hormone receptor binding; hormone activity. Biological Process: epidermis development; negative regulation of transcription factor activity; negative regulation of chondrocyte differentiation; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; osteoblast development; negative regulation of cell proliferation; cAMP metabolic process; epithelial cell differentiation; cell-cell signaling; regulation of gene expression; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; protein processing; skeletal development; alveolus development; surfactant homeostasis; endochondral ossification; endoderm development. Disease: Brachydactyly, Type E2

size1 :

0.01 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage