protein

IL7 protein (Mouse)

MBS538125

1 mg

5950 USD

Recombinant Protein

IL7 protein (Mouse)

IL7

IL 7; Lymphopoietin 1 (LP-1) protein; IL-7 protein; pre-B cell factor protein; IL 7 protein; Lymphopoietin 1protein; IL-7; Interleukin 7 protein; LP-1 protein; IL7

Interleukin 7; Interleukin-7; interleukin-7; interleukin 7

IL7

IL7; IL7; IL-7; IL-7

IL7_HUMAN

Mouse

177

> 98% pure

Supplied as a lyophilized powder. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein quantitation was carried out by two independent methods 1. UV spectroscopy at 280 nm using the absorbency value of 0.48 as the extinction coefficient for a 0.1% (1mg/ml) solution. 2. Analysis by RP-HPLC, using a standard solution of IL-7 as a Reference Standard.

Protein Type: Recombinant. Biological Significance: Interleukin-7 is a potent lymphoid cell growth factor produced primarily by stromal cells. IL-7 has been shown to support the proliferation and differentiation of pre B- and early T cells as well as displaying a biological effect on cells of NK and myeloid lineages. Bioactivity: The ED50 as determined by the dose-dependant stimulation of murine 2E8 cells is

Expression System: E Coli

Cytokines & Growth Factors

Purified recombinant Mouse IL7 protein

29126905

AAH47698.1

P13232

7,687 Da

Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Immune System Pathway 106386!!Interleukin-7 Signaling Pathway 530762!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!PI3K-Akt Signaling Pathway 692234

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

1 mg

5950 USD