protein

BCMA protein

MBS538091

0.02 mg

310 USD

Recombinant Protein

BCMA protein

BCMA

TNFRSF17 protein; BCM protein; B-Cell Maturation Antigen protein

BCMA; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily, member 17; B-cell maturation protein; CD_antigen: CD269

BCMA

TNFRSF17; TNFRSF17; BCM; BCMA; CD269; TNFRSF13A; BCM; BCMA

TNR17_HUMAN

Human

184

Region of BCMA protein corresponding to amino acids AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA.

> 98% pure

Supplied as a lyophilized powder

20ug, lyophilized

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

Expression System: E Coli

Cytokines & Growth Factors

Purified recombinant Human BCMA protein

14488254

BAB60895.1

Q02223

5.3 kDa

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670)

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. Protein type: Membrane protein, integral; Receptor, misc.; Oncoprotein. Chromosomal Location of Human Ortholog: 16p13.1. Cellular Component: integral to membrane; plasma membrane; endomembrane system. Molecular Function: receptor activity. Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction

0.02 mg

310 USD