catalog number :
MBS538033
products type :
Recombinant Protein
products full name :
Prokineticin 2 protein
products short name :
Prokineticin 2
products name syn :
PK2 protein; Prokineticin 2; Prokineticin-2 protein; Prokineticin 2 protein; Protein Bv8 homolog protein; PROK2 protein; Prokineticin-2
other names :
prokineticin-2 isoform 2; Prokineticin-2; prokineticin-2; prokineticin 2
other gene names :
Prok2; Prok2; Bv8; Bv8; PK2
uniprot entry name :
PROK2_RAT
sequence :
Region of Prokineticin 2 protein corresponding to amino acids AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTC PCLPGLACLR TSFNRFICLA QK.
form :
Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml.
storage stability :
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
User optimized
other info1 :
Protein Type: Recombinant. Biological Significance: Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and in lower levels of the small intestine. PK2 regulates various biological functions including gastrointestinal motility, angiogenesis and circadiam rhythms. It is closely related to EG-VEGF (Prokineticin-1) and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues and ten cysteine residues that potentially form five pairs of intra-molecular disulfide bonds. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
other info2 :
Expression System: E Coli
products categories :
Cytokines & Growth Factors
products description :
Purified recombinant Human Prokineticin 2 protein
ncbi acc num :
NP_620207.1
ncbi gb acc num :
NM_138852.1
ncbi mol weight :
8.8 kDa
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway 1177697!!G Alpha (q) Signalling Events Pathway 1177730!!GPCR Downstream Signaling Pathway 1177726!!GPCR Ligand Binding Pathway 1177696!!Gastrin-CREB Signalling Pathway Via PKC And MAPK 1177745!!Peptide Ligand-binding Receptors Pathway 1177698!!Signal Transduction Pathway 1177518!!Signaling By GPCR Pathway 1177695
ncbi summary :
ligand of of two orphan G-protein-coupled receptors designated ZAQ and I5E [RGD, Feb 2006]