SCF protein (Mouse) | MyBioSource MBS538024 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

SCF protein (Mouse)

catalog :

MBS538024

quantity :

0.01 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS538024

products type :

Recombinant Protein

products full name :

SCF protein (Mouse)

products short name :

SCF

products name syn :

c-Kit Ligand protein; Mast Cell Growth Factor protein; MGF protein; Steel Factor protein; Stem Cell Factor protein

other names :

stem cell factor, partial; Kit ligand; kit ligand; KIT ligand; Mast cell growth factor; MGF

products gene name :

SCF

other gene names :

KITLG; KITLG; SF; MGF; SCF; FPH2; FPHH; KL-1; Kitl; SHEP7; MGF; SCF; MGF; SCF; sKITLG

uniprot entry name :

SCF_HUMAN

host :

Mouse

sequence length :

sequence :

Region of SCF protein corresponding to amino acids MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA.

purity :

> 98% pure

form :

Lyophilized from 10mM Na3PO4, pH 6.5.

concentration :

10 ug per vial; lyophillized

storage stability :

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on Mouse cells, while Mouse and rat SCF are fully active on human cells. Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells is 1 x 10^5 units/mg. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

other info2 :

Expression System: E Coli

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Mouse SCF protein

ncbi gi num :

1246100

ncbi acc num :

AAB35922.1

ncbi mol weight :

18.3 kDa

ncbi pathways :

Adaptive Immune System Pathway (366160); C-MYB Transcription Factor Network Pathway (138073); Cell Cycle Pathway (198811); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (685535); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Diseases Of Signal Transduction Pathway (1183518)

ncbi summary :

This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q22. Cellular Component: extracellular space; cytoskeleton; cytoplasm; extracellular region; integral to membrane; plasma membrane. Molecular Function: protein binding; growth factor activity; cytokine activity; stem cell factor receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; embryonic hemopoiesis; germ cell programmed cell death; male gonad development; signal transduction; cell proliferation; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mast cell apoptosis; positive regulation of melanocyte differentiation; innate immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of Ras protein signal transduction; cell adhesion; neural crest cell migration; positive regulation of DNA replication. Disease: Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7

size1 :

0.01 mg

price1 :

310 USD

more info or order :

MyBioSource product webpage