protein

Cytokeratin 8 protein

MBS538022

0.1 mg

445 USD

Recombinant Protein

Cytokeratin 8 protein

[Cytokeratin 8]

[Cytokeratin 8 protein; Cytokeratin -8 protein; Cytokeratin -8; Cytokeratin 8; Keratin K8 protein]

[cytokeratin 8; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8; keratin 8, type II; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8]

[KRT8; KRT8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; CYK8; CK-8; K8]

K2C8_HUMAN

Human

482

>95% by SDS-PAGE

Lyophilized from 30mM Tris-HCL, pH 8.0 with 9.5M urea, 2 mM DTT, 2 mM EDTA and 10 mM methylammonium chloride. Reconstitute with 175 uL distilled water.

Ships ambient or refrigerated. Upon receipt store at 4°C lyophilized or at -20°C after reconstitution. Avoid freeze/thaws.

Isoelectric Point: 6.1

Suitable for protein standard in 1D and 2D SDS gelelectrophoresis, immunoassays and immunization.

Protein Type: Binding Protein. Biohazard: Not for human use. Use normal laboratory precautions when handlind reagent. For research purposes only. Grade: Recombinant Human . Biological Significance: Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin represents an excellent marker for the discrimination of specific subtypes of adenocarcinoma. Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18.

Expression System: E Coli

Cancer; Binding Protein

Purified recombinant Human Cytokeratin 8 protein

181573

AAA35763.1

P05787

56,608 Da

EGFR1 Signaling Pathway (198782); Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; nuclear matrix; costamere; cytoplasm; keratin filament; intermediate filament; intercellular junction; Z disc; nucleus; sarcolemma. Molecular Function: protein binding; protein complex binding; structural molecule activity. Biological Process: viral reproduction; tumor necrosis factor-mediated signaling pathway; response to other organism; sarcomere organization; response to hydrostatic pressure. Disease: Cirrhosis, Familial

0.1 mg

445 USD

0.25 mg

715