TGF beta 3 protein | MyBioSource MBS538020 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

TGF beta 3 protein

catalog :

MBS538020

quantity :

0.01 mg

price :

335 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS538020

products type :

Recombinant Protein

products full name :

TGF beta 3 protein

products short name :

[TGF beta 3]

products name syn :

[Transforming Growth Factor-beta3 protein; TGF beta-3 protein; TGFB3 protein; TGF beta-3; TGF-3b protein; TGF beta 3; TGF beta 3 protein]

other names :

[transforming growth factor beta-3 preproprotein; Transforming growth factor beta-3; transforming growth factor beta-3; transforming growth factor, beta 3]

products gene name :

[TGF beta 3]

other gene names :

[TGFB3; TGFB3; ARVD; RNHF; ARVD1; TGF-beta3; TGF-beta-3; LAP]

uniprot entry name :

TGFB3_HUMAN

host :

E.coli

sequence length :

412

purity :

> 98% by SDS-PAGE analysis and RP-HPLC.

form :

Protein solution containing 20% Ethanol and 0.12% Acetic Acid.

concentration :

0.25 mg/ml

storage stability :

Store at 4°C. For long term storage add a carrier protein (0.1% HSA or BSA).

tested application :

User optimized

app notes :

Biological activity: ED50 <0.05 ng/ml using the WHO Standard 98/608 as a direct comparison.

other info1 :

Contaminants: Endotoxin level is <0.1 ng/mg of rHu TGF-beta 3. Biohazard: Use normal laboratory precautions and techniques when handling this reagent. Grade: Highly pure . Protein Type: Recombinant . Species: Human . Residues: TGF-b3 Human Recombinant protein containing 112 amino acids. Biological Significance: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

other info2 :

Assay Information: Protein quantitation was carried out by two independent methods:. 1.- UV spectroscopy at 280 nm using the absorbency value of 1.718 as the extinction coefficient for a 0.1% (1 mg/ml) solution. 2.-Analysis by RP-HPLC, using a calibrated solution of TGF-b 3 as a Reference Standard.

products categories :

Cytokines & Growth Factors

products description :

Purified recombinant Human TGF beta 3 protein

ncbi gi num :

4507465

ncbi acc num :

NP_003230.1

ncbi gb acc num :

NM_003239.2

uniprot acc num :

P10600

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83106)

ncbi summary :

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

uniprot summary :

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Protein type: Ligand, receptor tyrosine kinase; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation. Chromosomal Location of Human Ortholog: 14q24. Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; extracellular region; plasma membrane; nucleus. Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity. Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; female pregnancy; SMAD protein nuclear translocation; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; uterine wall breakdown; positive regulation of filopodium formation; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; positive regulation of protein secretion; gut development; response to estrogen stimulus; negative regulation of DNA replication; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; alveolus development; positive regulation of DNA replication. Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

size1 :

0.01 mg

price1 :

335 USD

more info or order :

MyBioSource product webpage