protein

GDF11 protein

MBS538017

0.02 mg

310 USD

Recombinant Protein

GDF11 protein

GDF11

BMP-11 protein; GDF 11 protein; GDF-11 protein; GDF-11; Growth/Differentiation Factor-11 protein; GDF11; GDF 11

growth/differentiation factor 11; Growth/differentiation factor 11; growth/differentiation factor 11; growth differentiation factor 11; Bone morphogenetic protein 11; BMP-11

GDF11

GDF11; GDF11; BMP11; BMP-11; BMP11; GDF-11; BMP-11

GDF11_HUMAN

Human

407

Region of GDF11 protein corresponding to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS.

> 98% by SDS-PAGE analysis and HPLC

Sterile Filtered through a 0.2 micron filter. Lyophilized with no additives. Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/ml. Keep pH below 5.0. Do not vortex.

20 ug per vial: lyophilized

Ships ambient or refrigerated. Upon receipt store at -20 degree C. After reconstituted, the undiluted solution is stable at 4 degree C for up to 1 week. For extended storage, dilute further in a buffer containing a carrier protein and store in working aliquots at -20 degree C to -80 degree C. Avoid repeat freeze-thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Bioactivity: The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 ug/ml. Biohazard: Use normal laboratory precautions and techniques when handling this reagent. Endotoxin Levels: Endotoxin level is less than 0.1 ng/ug

Source: E Coli

Cytokines & Growth Factors

Purified recombinant Human GDF11 protein

5031613

NP_005802.1

NM_005811.3

O95390

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q13.2. Cellular Component: extracellular space. Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; metanephros development; skeletal development; cell development; growth

0.02 mg

310 USD