protein

Tryptase protein

MBS537974

0.005 mg

180 USD

Native Protein

Tryptase protein

Tryptase

Tryptase protein; TPS protein

tryptase; Tryptase alpha/beta-1; tryptase alpha/beta-1; tryptase alpha/beta 1; Tryptase I; Tryptase alpha-1

TPSAB1; TPSAB1; TPS1; TPS2; TPSB1; TPS1; TPS2; TPSB1; Tryptase-1

TRYB1_HUMAN

Human

275

> 95% pure

Supplied as a liquid in 0.05M NaOAc, pH 5 with 1M NaCl and 0.01% NaN3

0.95mg/ml (by UV absorbance at 280nm)

Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles

User optimized

Source Note: Human lung. Protein Type: Native. Biological Significance: Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has been used as a marker for mast cell activation. It is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines.

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Proteases, Inhibitors, Native Protein

Purified native Human Tryptase protein

1182067

AAA86934.1

Q15661

140 kDa

Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262)

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; EC 3.4.21.59; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis

0.005 mg

180 USD

0.01 mg

230

0.025 mg

310