protein

Angiopoietin 1 protein

MBS537938

0.02 mg

490 USD

Recombinant Protein

Angiopoietin 1 protein

Angiopoietin 1

Angiopoietin 1; ANG1 protein; AGP 1 protein; ANGPT1 protein; ANGPT 1 protein; ANG 1 protein; Angiopoietin -1 protein; AGPT protein; AGP1 protein; Angiopoietin -1; KIAA0003 protein; Angiopoietin 1 protein; Angiopoietin1 protein

angiopoietin-1 isoform 1; Angiopoietin-1; angiopoietin-1; angiopoietin 1

ANGPT1; ANGPT1; AGP1; AGPT; ANG1; KIAA0003; ANG-1

ANGP1_HUMAN

Human

498

> 95% pure

Supplied as a lyophilized powder. Reconstitute in PBS or water to a concentration not lower than 100 ug/ml, pH 7.4.

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation. Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase.

Expression System: HeLa Cells

Differentiation & Development

Purified recombinant Human Angiopoietin 1 protein

20532340

NP_001137.2

NM_001146.3

Q15389

60-70 kDa

Angiogenesis Pathway 198772!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!HIF-1 Signaling Pathway 695200!!Hemostasis Pathway 106028!!PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979!!Rap1 Signaling Pathway 868086!!Rap1 Signaling Pathway 878042!!Ras Signaling Pathway 868085

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

0.02 mg

490 USD