protein

Thyroid Peroxidase protein

MBS537891

0.1 mg

280 USD

Native Protein

Thyroid Peroxidase protein

Thyroid Peroxidase

TPO protein; MSA protein; TPX protein

thyroid peroxidase, partial; Thyroid peroxidase; thyroid peroxidase; thyroid peroxidase

TPO; TPO; MSA; TPX; TDH2A; TPO

PERT_HUMAN

Human

120

> 95% by SDS-PAGE analysis

Purified liquid in 20mM Tris, 50mM KCl, 0.1 mM KJ, pH 7.5. with no preservatives added.

1mg/ml

4 degree C for shipping purposes only. Upon receipt store at -20 degree C while lyophilized. After reconsituted, do not keep in liquid form for longer than 48 hours.

User optimized

Volume: 1.0ml. Source Note: Human thyroid glands. Protein Type: Native. Biological Significance: Thyroid peroxidase or thyroperoxidase (TPO) is an enzyme expressed mainly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene.

Grade: Highly Pure. Contaminants: None detects by SDS-PAGE. Biohazard: Tissue extract tested by EIA and found to be negative for HBsAg, anti-HIV 1/2 and anti-HCV. Additional Remarks: Suitable foruse in immunoassays as solid phase antigen.

Proteases, Inhibitors, Native Protein

Purified native Human Thyroid Peroxidase protein

5705932

AAB23677.2

Amine-derived Hormones Pathway (160983); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Thyroid Hormone Biosynthesis, Tyrosine = Triiodothyronine/thyroxine Pathway (413358); Thyroid Hormone Biosynthesis, Tyrosine = Triiodothyronine/thyroxine Pathway (468236); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

TPO: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). An alternative splicing in the thyroperoxidase mRNA can cause Graves disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A). A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Belongs to the peroxidase family. XPO subfamily. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 1.11.1.8; Mitochondrial; Amino Acid Metabolism - tyrosine; Oxidoreductase. Chromosomal Location of Human Ortholog: 2p25. Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; plasma membrane. Molecular Function: peroxidase activity; heme binding; iodide peroxidase activity; calcium ion binding. Biological Process: embryonic hemopoiesis; hydrogen peroxide catabolic process; thyroid hormone generation; hormone biosynthetic process; response to oxidative stress. Disease: Thyroid Dyshormonogenesis 2a

0.1 mg

280 USD