protein

Complement C9 protein

MBS537887

0.25 mg

485 USD

Native Protein

Complement C9 protein

Complement C9

C9 protein

complement component C9; Complement component C9; complement component C9; complement component 9

C9; C9; C9D; ARMD15

CO9_HUMAN

Human

559

> 95% pure

Supplied as a liquid in PBS, pH 7.2, no preservatives added,

1.03mg/ml

Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles. Shipping: Ships with Dry Ice.

Source Note: Human serum/plasma. Protein Type: Native. Biological Significance: Native human C9 is a naturally glycosylated (7.8%) protein composed of a single polypeptide chain. The molecular weight is 71,000 Da. C9 binds to the C5b-8 complex and forms the mature membrane attack complex (MAC) on cell membranes. Each pathway of complement activation generates proteolytic enzyme complexes (C3/C5 convertases) which are bound to the target surface. These enzymes cleave a peptide bond in the larger alpha chain of C5 releasing the anaphylatoxin C5a and activating C5b.

Biohazard Information: Use appropriate laboratory precautions when handling this product. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Functional Activity: 255,000kU/mg, >100% of C9 in NHS on a mg/mg basis.

Immunology; Native Protein; Complements

Purified Complement C9 protein isolated from human plasma

4502511

NP_001728.1

NM_001737.3

P02748

71 kDa

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Innate Immune System Pathway (106387); Prion Diseases Pathway (101144)

This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]

C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Apoptosis; Extracellular matrix. Chromosomal Location of Human Ortholog: 5p14-p12. Cellular Component: membrane attack complex; integral to plasma membrane; cytoplasm; extracellular region; plasma membrane. Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; hemolysis by symbiont of host red blood cells; complement activation, classical pathway. Disease: Macular Degeneration, Age-related, 15; Complement Component 9 Deficiency

0.25 mg

485 USD