protein

AFP protein

MBS537816

0.5 mg

560 USD

Native Protein

AFP protein

[AFP]

[alpha-FP protein; alpha-Fetoprotein protein]

[alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin]

[AFP]

[AFP; AFP; AFPD; FETA; HPAFP; HPAFP]

FETA_HUMAN

AFP cell line.

609

>95% by PAGE. Affinity purified

Supplied in 0.1M Tris buffer, 0.2M NaCI, pH 7.5 , 0.1% Na Azide

2.93 mg/mL (cobas AFP assay). Total protein: 4.10 mg/mL

Shipping: Blue ice. Upon receipt aliquot and freeze at -20°C or lower.

Control

Grade: Highly pure. Species: Human. Contaminants: None deteected by IEP and PAGE. Protein Type: Native. Biological Significance: Alpha-fetoprotein (AFP) is a protein that in humans is encoded by the AFP gene. Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem on chromosome 4.

Biohazard Information: The cell line supernant tested negative for HCV Ab, HIV-1/2 Ab, HIV-1 and HBsAg and HCV by Nat per current FDA methods. Please note that the samples tested were Cell Culture Supernatants, not Serum and not appropiate for use in these Assays. Handle as through infectious.

Cancer; Native Protein

Purified Human AFP protein from cell culture supernatent

Simultaneous multianalysis for tumor markers by antibody fragments microarray system; Shi-Ping Songa, Bin Lia, Jun Hua, Min-Qian Li (Analytica Chimica Acta: Volume: 510 Issue: 2 Page: 147-152 DOI: 10.1016/j.aca.2004.01.020). Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein; Young Ju Lee, Seong-Wook Lee (Biochemical and Biophysical Research Communications: Volume: 417 Issue: 1 Page: 521-527 DOI: 10.1016/j.bbrc.2011.11.153)

178236

AAB58754.1

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

0.5 mg

560 USD