protein

MPO protein

MBS537657

1 mg

1430 USD

Native Protein

MPO protein

MPO

Myeloperoxidase Protein

myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase

MPO

MPO; MPO; MPO

PERM_HUMAN

Human

745

> 90% pure

Supplied as a lyophilized powder

1.0 mg per vial; lyophilized

Store at -20 degree C in lyophilised and reconstituted forms. Aliquot following reconstitution and avoid repeated freeze/thaw cycles.

User optimized

Source Note: Human donor leukocytes. Protein Type: Native. Biological Significance: MPO is an enzyme contained in azurophilic granules (MW ca. 140 kDa) and it is a covalently linked complex of two alpha chains (MW ca. 60 kDa) and two beta chains (MW ca. 14 kDa). MPO is considered as one of the most promising cardiac markers to identify patients with chest pain that are at increased risk of cardiovascular events. Anti-MPO autoantibodies are serological markers for certain systemic vasculitides.The purified MPO antigen can be used for the detection of anti-MPO autoantibodies in immunoassays, in immunochemical and biochemical MPO studies.

Biohazard Information: Donor samples were tested and found to be negative for HBsAg, HCV, HIV-1 and 2 antibodies, and syphilis. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

Immunology; Native Protein

Purified nativeHuman MPO protein

4557759

NP_000241.1

NM_000250.1

P05164

87,248 Da

C-MYB Transcription Factor Network Pathway (138073); Folate Metabolism Pathway (198833); IL23-mediated Signaling Events Pathway (138000); Phagosome Pathway (153910); Phagosome Pathway (153859); Selenium Pathway (198825); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); Vitamin B12 Metabolism Pathway (920974); Amb2 Integrin Signaling Pathway (137945)

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.11.2.2. Chromosomal Location of Human Ortholog: 17q23.1. Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule. Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding. Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; response to lipopolysaccharide; defense response; response to yeast; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis. Disease: Myeloperoxidase Deficiency; Alzheimer Disease

1 mg

1430 USD