catalog number :
MBS537508
products type :
Recombinant Protein
products full name :
Bacillus Anthracis (Anthrax) protein (Protective Antigen)
products short name :
[Bacillus Anthracis]
products name syn :
[Bacillus Anthracis Protein; Bacillus anthracis Protective Nicked Antigen; Anthrax Protein; Recombinant B Anthracis]
other names :
[Bacillus anthracis protective antigen, partial]
form :
Lyophilized from 10mM BIS-Tris propane, pH 8.5, with 1.25% trehalose. Reconstitute in sterile 50% Glycerol or sterile distilled water to a final concentration of 1mg/ml. Addition of BSA may enhance stability.
concentration :
100ug lyophilized
storage stability :
Shipping: Blue Ice; After receipt, store at 4°C.
tested application :
User optimized.
other info1 :
Species: Viral. Grade: Recombinant
products categories :
Infectious Disease
products description :
PA63 is the carboxyl-terminal 63- kDa fragment obtained by the proteolytic cleavage of the receptor-bound protective antigen (PA), one of the three proteins that comprise anthrax toxin. Unlike native PA, PA 63 oligomerizes to form a ring-shaped heptamer that binds up to three copies of EF and/or LF competitively and with high affinity (kDa ~1 nM). Whereas native PA persists on the cell surface, the heptamer is endocytosed, presumably because oligomerization aggregates anthrax toxin receptor. The endocytosed toxic complexes are trafficked to endosomal compartments where the low pH causes the PA63 heptamer to insert into the membrane and form a water-filled channel.
ncbi acc num :
ABU63125.1
ncbi mol weight :
Major band at 63kDa, by SDS-PAGE