protein

TBG protein (> 98% pure)

MBS537507

1 mg

395 USD

Native Protein

TBG protein (> 98% pure)

TBG

T4 Binding Globulin protein; Thyroxine Binding Globulin protein; TBG protein

thyroxine-binding globulin; Thyroxine-binding globulin; thyroxine-binding globulin; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Serpin A7; T4-binding globulin

TBG

SERPINA7; SERPINA7; TBG; TBG

THBG_HUMAN

Human

415

> 98% pure

Lyophilized from 0.02M NH4HCO3.

1.0 mg; lyophilized

Store at 4 degree C.

User optimized

Source Note: Human plasma. Protein Type: Native. Biological Significance: Thyroxine-binding globulin (TBG) binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3?-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood.

Contaminants: None detected by SDS PAGE analysis

Hormones & Steroids; Native Protein

Purified native Human TBG protein

205277441

NP_000345.2

NM_000354.5

P05543

660 kDa

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: Xq22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; hormone binding. Biological Process: response to drug; response to peptide hormone stimulus; response to corticosterone stimulus; response to vitamin A; aging; post-embryonic development

1 mg

395 USD