product summary
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company name :
MyBioSource
product type :
protein
product name :
Complement C4 protein
catalog :
MBS537469
quantity :
1 mg
price :
460 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS537469
products type :
Native Protein
products full name :
Complement C4 protein
products short name :
Complement C4
products name syn :
C4 protein
other names :
complement C4; Complement C4; complement C4; complement component 4A (Rodgers blood group)
other gene names :
C4a; C4; C4; C4b; C4-1; C4a
uniprot entry name :
CO4_RAT
host :
Human
sequence length :
1737
purity :
> 99% pure
form :
Na3PO4 buffer, pH 7.0, with 150mM NaCl, and 0.09% NaN3.
storage stability :
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
other info1 :
Source Note: Human plasma. Protein Type: Native. Biological Significance: Component C4 interacts with C1 and C2 to form C3 convertase of the classic activation pathway. Systemic lupus erythematosus (SLE) is often associated with congenital C4 deficiency. Reduced levels of components of the classic pathway (C1, C2, C4, C3) are common after such activation, e.g. in SLE, acute serum sickness and conditions associated with circulating immune complexes. The common form present in plasma and used in diagnostics assays is the C4c form offered here.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
products categories :
Immunology; Native Protein; Complements
products description :
Purified Complement C4 protein isolated from human plasma
ncbi gi num :
158186621
ncbi acc num :
NP_113692.2
ncbi gb acc num :
NM_031504.3
uniprot acc num :
P08649
ncbi mol weight :
210 kDa
ncbi pathways :
Activation Of C3 And C5 Pathway (1177956); Complement Activation, Classical Pathway (198509); Complement And Coagulation Cascades Pathway (198461); Complement And Coagulation Cascades Pathway (83465); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1177949); Immune System Pathway (1177885); Initial Triggering Of Complement Pathway (1177950); Innate Immune System Pathway (1177914); Pertussis Pathway (218108)
ncbi summary :
complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD, Feb 2006]
uniprot summary :
C4A: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. Protein type: Inhibitor; Secreted; Secreted, signal peptide. Cellular Component: extracellular space; extracellular region. Molecular Function: complement component C1q binding; endopeptidase inhibitor activity. Biological Process: innate immune response; inflammatory response; complement activation, classical pathway; complement activation
size1 :
1 mg
price1 :
460 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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