MyBioSource

protein

Fibrinogen protein

MBS537444

1 g

480 USD

MBS537444

Native Protein

Fibrinogen protein

Fibrinogen

Fg protein

fibrinogen; Fibrinogen gamma-B chain; fibrinogen gamma-B chain; gamma'; fibrinogen, gamma polypeptide; fibrinogen gamma chain<; N/A

FGG; FGG; Gamma'

FIBG_BOVIN

Human plasma

Human

100% clottable. Grade: Standard

Purified, supplied in 20 mM Sodium Citrate-HCl buffer, pH 7.4. When thawing, warm to 37 degree C to assure complete protein solubility. Once thawed do not chill. Remaining protein may be aliquoted into single use size and frozen at - 70 degree C or below.

43.77 mg/ml

Upon receipt store at -70 deg C or lower. Avoid repeated freeze/thaw cycles

Contaminants: Plasminogen has been depleted by affinity chromatography.

Biohazard Information: Purified from human plasma which tested negative by FDA accepted methods for anti-HIV1/2, anti-HTLV I&II, HBsAg, anti-HCV, syphilis, HBC Ab, HIV-1 p24 or HIV-1 RNA, HCV RNA and HBV RNA. Donnors are screened for CJD.

Immunology; Proteins; Native & Recombinant Proteins; Native

Highly purified native Fibrinogen protein. Fibrinogen (factor I) is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for converting fibrinogen into fibrin.

350

CAA33562.1

P12799

50,244 Da

Common Pathway 581633!!Complement And Coagulation Cascades Pathway 84312!!Complement And Coagulation Cascades Pathway 484!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 581630!!GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway 581487!!Hemostasis Pathway 581607!!Integrin AlphaIIb Beta3 Signaling Pathway 581486!!Integrin Cell Surface Interactions Pathway 581485!!Platelet Aggregation (Plug Formation) Pathway 581625!!Platelet Activation, Signaling And Aggregation Pathway 581617

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain . By similarity. Subcellular location: Secreted. Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure. Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sequence similarities: Contains 1 fibrinogen C-terminal domain.

1 g

480 USD