protein

Complement C1q protein

MBS537423

1 mg

490 USD

Native Protein

Complement C1q protein

Complement C1q

C1q protein

complement C1q subcomponent subunit B; Complement C1q subcomponent subunit B; complement C1q subcomponent subunit B; complement component 1, q subcomponent, B chain

C1QB; C1QB

C1QB_HUMAN

Human

253

> 98% pure

10mM HEPES, 300mM NaCl, pH 7.2.

1.1 mg/ml. Activity: 555,000 U/mg

Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles.

Source Note: Human serum/plasma. Protein Type: Native. Biological Significance: C1q is part of the C1 complex and this complex is the first complement component in the cascade referred to as the classical pathway of complement. C1 is actually a non-covalent assembly of three different proteins (C1q, C1r, and C1s) bound together in a calcium-dependent complex. C1q has six extended arms with domains at the end of each arm that bind to the Fc domains of immunoglobulins. Bioactivity: >1,000,000 C1H50 units/mg

Biohazard Information: Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Immunology; Native Protein; Complements

Purified Complement C1q protein isolated from human plasma

87298828

NP_000482.3

NM_000491.3

P02746

410 kDa

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]

C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p36.12. Cellular Component: collagen; extracellular region; complement component C1 complex. Molecular Function: protein binding; protein homodimerization activity. Biological Process: innate immune response; complement activation, classical pathway; inner ear development; complement activation. Disease: C1q Deficiency

1 mg

490 USD