product summary
Loading...
company name :
MyBioSource
product type :
protein
product name :
Intrinsic Factor protein (Pig)
catalog :
MBS537394
quantity :
0.1 mg
price :
745 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS537394
products type :
Native Protein
products full name :
Intrinsic Factor protein (Pig)
products short name :
Intrinsic Factor
products name syn :
Porcine Intrinsic Factor; Pig Intrinsic Factor; Swine Intrinsic Factor; Porcine IF protein
other names :
intrinsic factor; Gastric intrinsic factor; Intrinsic factor; IF; INF
other gene names :
GIF; IFMH; IF; INF
uniprot entry name :
IF_HUMAN
host :
Pig
sequence length :
417
purity :
> 95% pure
form :
Supplid in distilled water.
concentration :
0.5 mg/ml (by B12 Binding Assays)
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles. Shipping: Ships with Dry Ice.
tested application :
User optimized
app notes :
Purity based B12 binding assays performed with bother Cobinamide and anti-Intrinsic Factor blocking antibodies.
other info1 :
Source Note: Prepared from porcine gastric mucosa. Protein Type: Native. Biological Significance: Intrinsic factor (IF) also known as gastric intrinsic factor (GIF) is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the terminal ileum. In humans, the gastric intrinsic factor protein is encoded by the GIF gene. Bioactivity: 30 ug of B12-binding ability per mg of protein. Grade: Highly Pure
other info2 :
Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Contaminants: Single band on SDS-PAGE in the presence of reducing reagents. Biohazard: This product is producedfrom hog stomach. As with any material produced from animal tissue, ti is recommended to observe full safety precautions when handling this material.
products categories :
Nutrition & Metabolism; Native Protein
products description :
Purified Porcine Intrinsic Factor protein
ncbi gi num :
183186
ncbi acc num :
AAA66354.1
ncbi mol weight :
42,698 Da
uniprot summary :
GIF: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. Defects in GIF are the cause of hereditary intrinsic factor deficiency (IFD); also known as congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: lysosomal lumen; extracellular space; microvillus; apical plasma membrane; extracellular region; endosome. Molecular Function: cobalamin binding. Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process. Disease: Intrinsic Factor Deficiency
size1 :
0.1 mg
price1 :
745 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!