Calcitonin Peptide | MyBioSource MBS537384 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Calcitonin Peptide

catalog :

MBS537384

quantity :

1 mg

price :

560 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS537384

products type :

Recombinant Protein

products full name :

Calcitonin Peptide

products short name :

Calcitonin

other names :

calcitonin; Calcitonin; calcitonin; calcitonin gene-related peptide 1; calcitonin-related polypeptide alpha; CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP

other gene names :

CALCA; CALCA; CT; KC; CGRP; CALC1; CGRP1; CGRP-I; CALC1; CCP

uniprot entry name :

CALC_HUMAN

host :

Human

sequence length :

141

purity :

> 95% pure

form :

Supplied as a lyophilized powder. Reconstitute with distilled water.

concentration :

1.0 mg per vial

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles

tested application :

User optimized

other info1 :

Protein Type: Recombinant. Biological Significance: Calcitonin is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).

other info2 :

Biohazard Information: Recombinant proteins are not considered infectious. However, recombinant proteins can be potent immunogens capable of eliciting a strong antibody response. Use appropriate laboratory safety precautions when handling this product. Expression System: Synthetically derived

products categories :

Hormones & Steroids

products description :

Purified recombinant Human Calcitonin Peptide

ncbi gi num :

179820

ncbi acc num :

AAA58403.1

uniprot acc num :

P01258

ncbi mol weight :

3.4 kDa

ncbi pathways :

Amyloids Pathway (366238); Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); Disease Pathway (530764); Endothelin Pathway (672453); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Myometrial Relaxation And Contraction Pathways (198759); Signal Transduction Pathway (477114)

ncbi summary :

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

uniprot summary :

CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 11p15.2. Cellular Component: extracellular space; cell soma; cytoplasm; extracellular region; terminal button; nucleus. Molecular Function: identical protein binding; protein binding; calcitonin receptor binding; hormone activity; protein complex binding; receptor binding. Biological Process: negative regulation of osteoclast differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of interleukin-1 alpha production; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure; response to pain; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; protein amino acid phosphorylation; positive regulation of interleukin-8 production; monocyte chemotaxis; leukocyte adhesion; elevation of cytosolic calcium ion concentration; vasculature development; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; receptor internalization; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; negative regulation of ossification; feeding behavior; negative regulation of blood pressure; positive regulation of adenylate cyclase activity; detection of temperature stimulus involved in sensory perception of pain; negative regulation of bone resorption; positive regulation of macrophage differentiation; inflammatory response; negative regulation of neurological process; aging; cytosolic calcium ion homeostasis; regulation of heart rate; adenylate cyclase activation; positive regulation of ossification; regulation of systemic arterial blood pressure by neurological process; G-protein coupled receptor internalization; response to heat; endothelial cell proliferation; regulation of inflammatory response; activation of protein kinase activity; endothelial cell migration; negative regulation of transcription, DNA-dependent; embryo implantation

size1 :

1 mg

price1 :

560 USD

more info or order :

MyBioSource product webpage