Collagen Type II protein | MyBioSource MBS537376 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Collagen Type II protein

catalog :

MBS537376

quantity :

0.1 mg

price :

1015 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS537376

products type :

Native Protein

products full name :

Collagen Type II protein

products short name :

[Collagen Type II]

products name syn :

[Cartilage collagen; COL11A3; Chondrocalcin; COL2A1]

other names :

[Collagen, type II, alpha 1; Collagen alpha-1(II) chain; collagen alpha-1(II) chain; collagen, type II, alpha 1; Alpha-1 type II collagen]

other gene names :

[COL2A1; COL2A1; AOM; ANFH; SEDC; STL1; COL11A3]

uniprot entry name :

CO2A1_HUMAN

host :

Adult knee cartilage

sequence length :

1487

form :

Sterile filtered liquid in 0.5M Acetic Acid buffer with 0.01% Sodium Azide as preservative.

concentration :

1.0 mg/mL

storage stability :

Store at 4°C. Use within 6 months from date of opening.

tested application :

User optimized

other info2 :

Biohazard: Source material have been for the detection of HIV antibody, Hepatitis B surface antigen, antibody to Hepatitis C, HIV I (antigens), antibody to HTLV-I/II and syphilis by FDA approved methods. All units were found to be non-reactive/negative. Since no test assures complete safety, use appropriate laboratory precautions when handling this product. Species: Human. Protein Type: Native

products categories :

Cancer; Native Protein

products description :

Type-II collagen is the basis for articular cartilage and hyaline cartilage. It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage. Type II collagen does form fibers. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.

ncbi gi num :

95132445

ncbi acc num :

AAI16450.1

uniprot acc num :

P02458

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795)

ncbi summary :

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

COL2A1: the alpha-1 chain of type II collagen, an extra-cellular matrix protein found in cartilage and the vitreous humor of the eye. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Chondrocalcin is the calcium binding C-propeptide of this collagen molecule. Defects in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. There are two transcripts identified for this gene. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Extracellular matrix; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q13.11. Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type II; extracellular region; basement membrane. Molecular Function: identical protein binding; platelet-derived growth factor binding; metal ion binding; extracellular matrix structural constituent conferring tensile strength. Biological Process: heart morphogenesis; axon guidance; proteoglycan metabolic process; extracellular matrix organization and biogenesis; inner ear morphogenesis; collagen fibril organization; central nervous system development; palate development; notochord development; limb bud formation; extracellular matrix disassembly; collagen catabolic process; sensory perception of sound; visual perception; regulation of gene expression; cartilage development; tissue homeostasis; chondrocyte differentiation; skeletal development; endochondral ossification; cartilage condensation. Disease: Achondrogenesis, Type Ii; Kniest Dysplasia; Epiphyseal Dysplasia, Multiple, With Myopia And Conductive Deafness; Spondyloperipheral Dysplasia; Legg-calve-perthes Disease; Osteoarthritis With Mild Chondrodysplasia; Stickler Syndrome, Type I; Czech Dysplasia; Platyspondylic Lethal Skeletal Dysplasia, Torrance Type; Otospondylomegaepiphyseal Dysplasia; Spondyloepimetaphyseal Dysplasia, Strudwick Type; Spondyloepiphyseal Dysplasia Congenita; Avascular Necrosis Of Femoral Head, Primary; Stickler Syndrome, Type I, Nonsyndromic Ocular

size1 :

0.1 mg

price1 :

1015 USD

more info or order :

MyBioSource product webpage