protein

SSB La protein

MBS537359

0.2 mg

625 USD

Native Protein

SSB La protein

SSB La

SSB protein; Single stranded binding protein; Single stranded binding La protein

Sjogren syndrome antigen B (autoantigen La); Lupus La protein; lupus La protein; Sjogren syndrome antigen B (autoantigen La); La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B

SSB La

SSB; SSB; La; LARP3; La/SSB; SS-B

LA_HUMAN

Bovine

408

> 90% pure

20mM Hepes-NaOH, pH 7.4, with 0.32M NaCl, 0.2mM dithiothreitol, 0.1mM PMSF, 20% glycerol, and stabilizers.

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

ELISA (EIA)

0.5-1 ug/ml

Source Note: Calf Thymus. Protein Type: Native. Biological Significance: La antigen binds to the oligo(U) 3' termini of nascent RNA polymerase III transcripts and facilitates transcriptional termination and reinitiation by this enzyme13,-17. It has also been reported to function as an ATP-dependent helicase able to melt RNA-DNA hybrids.

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Cancer; Native Protein

Purified native Bovine SSB La protein

18089160

AAH20818.1

48 kDa

Gene Expression Pathway (105937); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); RNA Polymerase III Abortive And Retractive Initiation Pathway (160949); RNA Polymerase III Transcription Pathway (106561); RNA Polymerase III Transcription Termination Pathway (106567); Systemic Lupus Erythematosus Pathway (83122); Systemic Lupus Erythematosus Pathway (534)

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3 termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs. Protein type: Transcription initiation complex. Chromosomal Location of Human Ortholog: 2q31.1. Cellular Component: nucleus; ribonucleoprotein complex. Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding. Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification

0.2 mg

625 USD