protein

Tropomyosin protein

MBS537318

0.1 mg

565 USD

Native Protein

Tropomyosin protein

[Tropomyosin]

[tropomyosin; Tropomyosin beta chain; tropomyosin beta chain; tropomyosin 2 (beta); Beta-tropomyosin; Tropomyosin-2]

[TPM2; TPM2; DA1; DA2B; NEM4; TMSB; AMCD1; HEL-S-273; TMSB]

TPM2_HUMAN

284

> 95% pure (by SDS-PAGE)

Supplied as a liquid in 50mM Sodium Chloride, 10mM Tris-HCl, 1mM EDTA, 5mM beta-Mercaptoethanol, 1mM EDTA, pH7.4 with 0.09% NaN3.

7.8mg/ml

Upon receipt store at -20 degree C. Avoid repeated freeze/thaw cycles. Shipping: Ships on Dry Ice.

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Source: Human cardiac tissue . Source Note: Prepare from Human cardiac tissue. Grade: Highly Pure. Protein Type: Native. Biological Significance: Tropomyosin is an actin-binding protein that regulates actin mechanics. It is important, among other things, for muscle contraction. Tropomyosin, along with the troponin complex, associate with actin in muscle fibers and regulate muscle contraction by regulating the binding of myosin. In resting muscle, tropomyosin overlays the myosin binding sites on actin, with a single tropomyosin molecule spanning 7 actin subunits, and is "locked" down in this position by troponin T (tropomyosin binding troponin) and troponin I (inhibitory troponin). Contaminants: Single band by SDS-PAGE

Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Biohazard: This product has been tested at serum donor level by an FDA approved methods and found negative for HIV1/2, HCV antibodies and Hepatitis B surface antigen. Since no test can offer complete assurance, handle with precaution.

Cancer; Native Protein

Purified native Human Tropomyosin protein

339731

AAB59509.1

P07951

28,684 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261); Smooth Muscle Contraction Pathway (161025)

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

TPM2: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Defects in TPM2 are the cause of nemaline myopathy type 4 (NEM4). A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life. Defects in TPM2 are the cause of distal arthrogryposis type 1A (DA1A). A form of distal arthrogryposis, a disease characterized by congenital joint flexures or contractures that mainly involve the distal parts of the limbs, and affect two or more different body areas in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Belongs to the tropomyosin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: cytosol; muscle thin filament tropomyosin. Molecular Function: structural constituent of muscle; actin binding. Biological Process: regulation of ATPase activity; muscle contraction; muscle filament sliding. Disease: Nemaline Myopathy 4; Arthrogryposis, Distal, Type 1a; Myopathy, Congenital, With Fiber-type Disproportion; Arthrogryposis, Distal, Type 2b

0.1 mg

565 USD