Mouse IgG Blocking Reagent | MyBioSource MBS537317 product information

product summary

company name :

MyBioSource

product type :

other

product name :

Mouse IgG Blocking Reagent

catalog :

MBS537317

quantity :

20 mg

price :

280 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS537317

products type :

Immunoglobulin

products full name :

Mouse IgG Blocking Reagent

products short name :

[Mouse IgG Blocking Reagent]

products name syn :

[Blocker of Human Anti-Mouse Immunoglobulin G Antibodies]

other names :

[albumin; Serum albumin; serum albumin; albumin]

products gene name :

[IgG]

other gene names :

[ALB; ALB; FDAH; ANALBA; PRO0883; PRO0903; PRO1341]

uniprot entry name :

ALBU_HUMAN

isotype :

IgG

sequence length :

609

form :

Supplied in sodium phosphate buffered 0.015M NaCl-PBS, pH 7.3, wirh 1000ppm 5-Nitro-5-Bromo-1.3-Dioxane

concentration :

8.4mg/ml by OD 280nm

storage stability :

Store at 4 degree C. DO NOT FREEZE.

tested application :

User optimized

app notes :

Used to block specific Human anti Mouse IgG antibodies (HAMA) which may potentially interfere in two-site (double antibody sandwich) and competitive immunoassays. Recommended starting concentration is 200-250ug/ml. Concentration range for optimization work is 50ug to 1mg per ml.

other info1 :

Source: Mouse. Biological Significance: Heterophilic Antibodies are a group of human antibodies against animal IgG. HA interference is a well known interference factor in diagnostic assays, often causing false positive results. The most known Heterophilic Antibody interference is HAMA. HA to other animals such as Goat (HAGA), Sheep (HASA), Rabbit (HARA), etc. may also cause false results. The frequency of such interference is low, but the false results have significant impact on the quality and competitiveness of the diagnostic assays as well as on the lives of those individuals who have been falsely diagnosed. Treatment of substrates with a suitable blocking agent can reduce such non-specific binding activity.

other info2 :

Biohazard: Use standard laboratory precautions when handling this material.

products categories :

Immunology; Biological Reagents; Controls & Calibrators

products description :

Mouse IgG (H + L) Blocking Reagent

ncbi gi num :

178344

ncbi acc num :

AAA98797.1

uniprot acc num :

P02768

ncbi mol weight :

45,160 Da

ncbi pathways :

Bile Acid And Bile Salt Metabolism Pathway (106144); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Platelet Activation, Signaling And Aggregation Pathway (106034)

ncbi summary :

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

uniprot summary :

albumin: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Plasma. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Carrier; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; protein complex; extracellular region; basement membrane; nucleus. Molecular Function: antioxidant activity; toxin binding; protein binding; enzyme binding; copper ion binding; DNA binding; zinc ion binding; chaperone binding; drug binding; oxygen binding; fatty acid binding; pyridoxal phosphate binding. Biological Process: platelet activation; receptor-mediated endocytosis; sodium-independent organic anion transport; bile acid metabolic process; maintenance of mitochondrion localization; lipoprotein metabolic process; hemolysis by symbiont of host red blood cells; cellular response to starvation; bile acid and bile salt transport; response to organic substance; response to mercury ion; retinal homeostasis; platelet degranulation; transport; negative regulation of programmed cell death; blood coagulation; transmembrane transport; positive regulation of circadian sleep/wake cycle, non-REM sleep; response to nutrient; negative regulation of apoptosis. Disease: Analbuminemia; Hyperthyroxinemia, Familial Dysalbuminemic

size1 :

20 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage