protein

TBG protein (> 95% pure)

MBS537300

1 mg

215 USD

Native Protein

TBG protein (> 95% pure)

TBG

T4 Binding Globulin protein; Thyroxine Binding Globulin protein

thyroxine-binding globulin; Thyroxine-binding globulin; thyroxine-binding globulin; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Serpin A7; T4-binding globulin

TBG

SERPINA7; SERPINA7; TBG; TBG

THBG_HUMAN

Human

415

> 95% pure

10mM PBS, pH 7.4, with 0.05% NaN3.

3.64 mg/ml (by RID using the Behring standard).

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Source Note: Human serum. Protein Type: Native. Biological Significance: Thyroxine-binding globulin (TBG) binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3?-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration.

Biohazard Information: Donor samples were tested and found to be negative for  HIV I/II, and HCV antibodies, and Hepatitis B surface antigen. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Hormones & Steroids; Native Protein

Purified native Human TBG protein (> 95% pure)

205277441

NP_000345.2

NM_000354.5

P05543

60 kDa

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: Xq22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; hormone binding. Biological Process: response to drug; response to peptide hormone stimulus; response to corticosterone stimulus; post-embryonic development; aging; response to vitamin A

1 mg

215 USD