catalog number :
MBS537279
products type :
Native Protein
products full name :
Prothrombin protein (Bovine)
products short name :
[Prothrombin]
products name syn :
[Bovine Prothrombin Protein]
other names :
[prothrombin; Prothrombin; prothrombin; Coagulation factor II]
other gene names :
[F2; F2]
uniprot entry name :
THRB_BOVIN
form :
Supplied as a liquid in 50% (vol/vol) glycerol/deionized water.
concentration :
9.6 mg/ml
storage stability :
Upon receipt store at -20 degree C. Avoid repeated Freeze/Thaw cycles. Shipping: 4 degree C only.
tested application :
User optimized
other info1 :
Source: Prepare from bovine fresh plasma. Protein Type: Native. Biological Significance: Prothrombin is a vitamin K-dependent plasma protein which is synthesized in the liver. Prior to secretion into plasma, prothrombin undergoes post-translational modification by a vitamin K-dependent carboxylase which converts ten specific glutamic acid residues to gamma-carboxyglutamic acid (gla). The ten gla residues are located within the first 40 amino acids of the mature protein and contribute to the ability of prothrombin to bind to negatively charged phospholipid membranes. Contaminants: Molecular Weight: 72,000 daltons E1%, 1cm, 280nm = 14.4
other info2 :
Biohazard Information: Use appropriate laboratory precautions while hanlding this product. For in VITRO research use only, is not inteded for clinical or diagnostic use.
products categories :
Immunology; Native Protein
products description :
Purified native Bovine Prothrombin protein
ncbi acc num :
NP_776302.1
ncbi gb acc num :
NM_173877.1
ncbi pathways :
Cell Surface Interactions At The Vascular Wall Pathway (1176324); Class A/1 (Rhodopsin-like Receptors) Pathway (1176908); Common Pathway Of Fibrin Clot Formation (1176322); Complement And Coagulation Cascades Pathway (920919); Complement And Coagulation Cascades Pathway (84312); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1176319); G Alpha (q) Signalling Events Pathway (1176940); GPCR Downstream Signaling Pathway (1176936); GPCR Ligand Binding Pathway (1176907)
uniprot summary :
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing ().