protein

Thyroglobulin protein

MBS537264

1 mg

215 USD

Native Protein

Thyroglobulin protein

[Thyroglobulin]

[hTg protein; Tg protein]

[thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin]

[TG; TG; TGN; AITD3; Tg]

THYG_HUMAN

Human

2767

> 98% pure by SDS-PAGE

White/off-white powder, lyophilized from 0.02M NH 4 HCO 3 . Reconstitute with a Phosphate Buffer solution, pH > 7.0 containing 0.15M NaCl

1.0mg, Lyophilized

4 degree C lyophilized, after reconstitution aliquot and store at -20 degree C or below.

User optimized

Source: Human thyroid tissue. Protein Type: Native. Biological Significance: Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as colloid. Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood.

Grade: Highly Pure. Biohazard: Pooled raw material tested negative for anti-HCV, anti-HIV I and II, HBsAg and Syphilis by FDA approved methods.

Hormones & Steroids; Native Protein

Purified native Human Thyroglobulin protein

37174

CAA29104.1

P01266

660 kDa

Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541); Thyroxine (Thyroid Hormone) Production Pathway (920992)

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8q24. Cellular Component: extracellular space; extracellular region. Molecular Function: hormone activity. Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process. Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3

1 mg

215 USD

10 mg

920