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protein

Troponin I protein (Cardiac)

MBS537260

1 mg

1685 USD

MBS537260

Native Protein

Troponin I protein (Cardiac)

Troponin I (Cardiac)

troponin I, cardiac muscle; Troponin I, cardiac muscle; troponin I, cardiac muscle; cardiac troponin I; Cardiac troponin I

TNNI3; TNNI3; N/A

TNNI3_CANFA

Human cardiac tissue

Human

0.1-5% of the total protein is Troponin I

Supplied frozen in 25mM TRIS buffer, pH 7.5, with 150mM NaCl, and 0.09% NaN3.

Aliquot and store at -20 deg C. Avoid repeated freeze/thaw cycles

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Cardiac Markers; Proteins; Native & Recombinant Proteins; Native

Purified native Human Troponin I protein (Cardiac) . Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.

50978684

NP_001003041.1

NM_001003041.1

Q8MKD5

100 kDa

Cardiac Muscle Contraction Pathway 93348!!Cardiac Muscle Contraction Pathway 93992!!Dilated Cardiomyopathy Pathway 121497!!Dilated Cardiomyopathy Pathway 121285!!Hypertrophic Cardiomyopathy (HCM) Pathway 114402!!Hypertrophic Cardiomyopathy (HCM) Pathway 106591!!Muscle Contraction Pathway 580369!!Striated Muscle Contraction Pathway 580370

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity . By similarity. Subunit structure: Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 . By similarity. Post-translational modification: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation increases myocardium contractile dysfunction . By similarity. Sequence similarities: Belongs to the troponin I family.

1 mg

1685 USD