Angiopoietin 2 protein | MyBioSource MBS537250 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Angiopoietin 2 protein

catalog :

MBS537250

quantity :

0.005 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS537250

products type :

Recombinant Protein

products full name :

Angiopoietin 2 protein

products short name :

Angiopoietin 2

products name syn :

Angiopoietin-2 protein; ANGPT 2 protein; Angiopoietin 2; Angiopoietin-2; Angiopoietin2 protein; ANGPT2 protein; Angiopoietin 2 protein; KIAA0003 protein; ANG 2 protein; ANG2 protein; AGP 2 protein; AGPT protein; AGP2 protein

other names :

Angiopoietin 2; Angiopoietin-2; angiopoietin-2; angiopoietin 2

other gene names :

ANGPT2; ANGPT2; ANG2; AGPT2; ANG-2

uniprot entry name :

ANGP2_HUMAN

sequence length :

496

purity :

> 95% by SDS-PAGE and HPLC

form :

Lyophilized from 10mM sodium phosphate buffer, pH8.0. Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not Vortex!

concentration :

20 ug lyophilized

storage stability :

Ships ambient or refrigerated; after receipt, store at 4 degree C short term, -20 degree C long term. Avoid repeated freeze/thaw cycles. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (e.g. 0.1% BSA) and store in working aliquots at -20 degree C.

tested application :

User optimized

other info1 :

Source: CHO cells. Protein Type: Recombinant. Biological Significance: The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation. Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase.

other info2 :

Expression System: Sf-9 insect cells. Contaminants: Endotoxin: <0.1ng/ug. Biohazard: Use appropriate laboratory precautions when handling this product.

products categories :

Differentiation & Development

products description :

Purified recombinant Human Angiopoietin 2 protein

ncbi gi num :

116496775

ncbi acc num :

AAI26201.1

uniprot acc num :

O15123

ncbi mol weight :

66 kDa

ncbi pathways :

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Cell Surface Interactions At The Vascular Wall Pathway (106062); HIF-1 Signaling Pathway (695200); Hemostasis Pathway (106028); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Rap1 Signaling Pathway (868086); Rap1 Signaling Pathway (878042); Ras Signaling Pathway (868085); Tie2 Signaling Pathway (106063)

ncbi summary :

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular space; cell projection; extracellular region; plasma membrane; nucleus. Molecular Function: protein binding; metal ion binding; receptor tyrosine kinase binding; receptor binding. Biological Process: organ regeneration; Tie receptor signaling pathway; maternal process involved in pregnancy; negative regulation of blood vessel endothelial cell migration; signal transduction; response to organic cyclic substance; germ cell development; negative regulation of positive chemotaxis; response to radiation; positive regulation of angiogenesis; negative regulation of angiogenesis; response to mechanical stimulus; response to hypoxia; response to glucose stimulus; angiogenesis; response to activity; blood coagulation; leukocyte migration

size1 :

0.005 mg

price1 :

255 USD

size2 :

0.02 mg

price2 :

490

more info or order :

MyBioSource product webpage