protein

Troponin T protein (Cardiac)

MBS537207

0.1 mg

525 USD

Native Protein

Troponin T protein (Cardiac)

[Troponin T]

[TnT protein]

[troponin T; Troponin T, cardiac muscle; troponin T, cardiac muscle; troponin T type 2 (cardiac); Cardiac muscle troponin T; cTnT]

[Tnnt2; Tnnt2; Ctt; CTTG; Tnnt3; RATCTTG; TnTc; cTnT]

TNNT2_RAT

Human Heart tissue

289

> 98% pure

Frozen liquid in 6M Urea, 50 mM Tris HCI, 0.25 NaCI, 15 mM beta-Mercaptoethanol, 1mM EDTA,pH 7.2

2.39 mg/ml

Ships on dry ice. Upon receipt store at -20°C or colder shor term, for long term storage -70°C. Avoid repeated freeze thaw .

User optimized

Contaminants: None detected. Protein Type: Native. Biological Significance: Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex. Troponin T binds to tropomyosin and helps position it on actin. And in a less complicated light, Troponin T modulates contraction of striated muscle.

Biohazard Information: Blood samples from tissue donors tested negative for HBsAg, Anti-HIV-1/HIV-2, HCV Ab and RPR/STS by FDA approved methods. However, the material should be viewed as potentially infectious and handled with caution.

Cardiac Markers; Native Protein

Purified native Human Troponin T protein (Cardiac)

207522

AAA42297.1

P50753

Adrenergic Signaling In Cardiomyocytes Pathway (908278); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Muscle Contraction Pathway (93346); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121476); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114014); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (1177800); Striated Muscle Contraction Pathway (1177801)

tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD, Feb 2006]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Motor. Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament. Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding. Biological Process: actin crosslink formation; atrial cardiac muscle morphogenesis; metabolic process; protein heterooligomerization; regulation of muscle contraction; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction

0.1 mg

525 USD